Here are Wednesday’s winning lottery numbers: The estimated Powerball jackpot is $264 million. The lump sum payment before taxes would be about $119.7 million.

The Powerball jackpot rose to $264 million after Monday's drawing. Check here for the winning numbers for July 16, 2025.

The winning numbers from the Wednesday, July 16 drawing are 4, 21, 43, 48 and 49. The Powerball was 22 . The Power Play multiplier was 2x. Check back to see if anyone won the Powerball jackpot.