Humans have been fond of decorating and changing their bodies for thousands — if not tens of thousands — of years. Ancient human remains have preserved ev ...

Epigenetic regulation of gene expression entails DNA methylation and histone modifications, which orchestrate chromatin structure and transcriptional activity. Aberrant regulation of these mechanisms ...

Before a newly synthesized protein can undergo folding, it must be processed and transported to the correct location within the cell after emerging from the ribosome. N-terminal acetylation ...

The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the next generation. Now, researchers from Kyushu University have demonstrated ...

A picture of a mouse MII stage eggs with the location of chromosomes (green) and the distribution of the histone modification H3K4me3 (purple). The team confirmed that H3K4me3 was significantly ...

Nucleosomes--which are composed of histone proteins (purple) wrapped in strands of DNA (green)--appear to regulate gene activity via inherent biophysical properties. For decades, scientists have known ...

Histone modification is an epigenetic mechanism that enables fine-tuning of gene expression. Mutation or dysregulation of proteins associated with histone modification (called “writers,” “erasers,” ...

LMU molecular biologist Gunnar Schotta decodes the epigenetic silencing of problematic retroviral gene sequences. While each cell contains the complete genetic blueprint of an organism, chemical marks ...

Introduction: Cardiac hypertrophy is characterized by significant metabolic changes, notably an increase in glycolysis. Histone lactylation, a post-translational modification influenced by the ...