San Diego joined MLS as the 30th team at the beginning of the season, and Columbus is the first Eastern Conference opponent for the franchise. On Tuesday, the Crew was knocked out of the CONCACAF Champions Cup round of 16 by Los Angeles FC. The early exit comes after Columbus reached the Champions Cup final last year.

The radio broadcast of Crew vs San Diego will be available on 105.7 FM and the iHeartRadio app with Chris Doran on the call. The Spanish radio broadcast, featuring Juan Valladares, will be available via 103.1 FM La Mega.