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Fast Degradation of MecciRNAs by SUPV3L1/ELAC2 Provides a Novel Opportunity to Tackle Heart Failure With Exogenous MecciRNA
Circular RNAs derived from both nuclear and mitochondrial genomes are identified in animal cells. Mitochondria-encoded circular RNAs (mecciRNAs) are attracting more attention, and several members of ...
eLife5y
Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons
Mitophagy, the selective removal of damaged mitochondria, is thought to be critical to maintain neuronal homeostasis. Mutations of proteins in the pathway cause neurodegenerative diseases, suggesting ...
eLife11y
Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors
IMCD3 cells stably expressing AP-SSTR3-GFP were seeded on 35-mm dishes. To deplete intracellular ATP, cells were either incubated in PBS with 20 μM Antimycin A and 10 mM 2-deoxyglucose (2DG) for 40 ...