Aiyuk signed a lucrative new deal with the 49ers last offseason. He played in seven games, catching 25 passes for 374 yards. Back in 2023, he racked up 75 receptions for 1,342 yards and seven touchdowns, showing legitimate No. 1 wide receiver potential.

Aiyuk would have to miss at least four games if he starts the regular season on the PUP list. The star wideout tore his ACL and MCL in his right knee on Oct. 20, so it's not a total shock. MORE: How good was LeBron at football? NBA legend would have been 'one of the best' in NFL

The San Francisco 49ers are waiting on Brock Purdy's weapon Brandon Aiyuk to come back from injury. Kyle Shanahan's playbook is too deep to waste.

San Francisco 49ers star Brandon Aiyuk got a major injury update ahead of training camp as he recovers from a torn ACL and MCL.

Wide receiver Jauan Jennings is seeking a contract extension from the 49ers before training camp opens next week, otherwise a trade request will be made, per a league source.

The 49ers and their fans continued to wonder about the health of Brandon Aiyuk. He received an important update Thursday.

San Francisco 49ers wide receiver Brandon Aiyuk reportedly could start the regular season on the reserve/physically unable to perform list as he rehabs from knee surgery.

Brandon Aiyuk has been a part of the San Francisco 49ers since being drafted in the first round of the 2020 NFL draft. The wide receiver has become a key part of the 49ers' offense.