1Department of Oncology, Mayo Clinic, Rochester, Minnesota.
Cancer Res (2025) 85 (5_Supplement): B038.
Major Finding: Hotspot KBTBD4 mutations in medulloblastoma mimic the mechanism of action of UM171 in degrading the CoREST corepressor complex. Concept: UM171 and recurrent KBTBD4 mutations analogously ...
Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...
1Department of Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas. 2Department of Biochemistry, The University of Texas Southwestern Medical Center at ...
President Donald Trump has issued a number of executive orders (EO) focused on healthcare for people who identify as lesbian, gay, bisexual, transgender, queer, or other sexual or gender minority.
Cancer Grand Challenges, Cancer Research UK, London, United Kingdom.
1Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China.
Downregulation of the major histocompatibility complex class I (MHCI) is a mechanism of immune evasion associated with immune-cold tumors, like prostate cancer. Chesner and colleagues conducted a ...
Major Finding: The lung microenvironment drives cancer-related thrombosis by secreting extracellular vesicles. Concept: Pro-thrombotic extracellular vesicles contain clustered integrin β 2, which ...
The EZH2 inhibitor mevrometostat, in combination with the androgen receptor signaling inhibitor enzalutamide, improved progression-free survival and objective response rates in patients with ...
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