NFL Week 6 Odds & Picks
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Week 5 of the 2025 NFL season kicked off with an overtime showdown between the 49ers and Rams on Thursday night. San Francisco secured the 26-23 win after stopping Los Angeles running back Kyren Williams on fourth-and-1 on the 11-yard line.
Next Gen Stats Insight for Texans-Ravens (via NFL Pro): Nick Chubb rushed for 61 yards on 11 carries with one touchdown, generating +33 rushing yards over expected. This marks his highest RYOE output this season and his most since Week 17, 2022.
SportsLine's top NFL experts reveal their NFL picks, NFL predictions, NFL betting tips and NFL best bets for Week 5
Stefon Diggs got his revenge against the Bills and Trevor Lawrence continued to show it's OK to be lucky, while Aaron Glenn hasn't had the same fortune with the Jets and Saquon Barkley hasn't been the same player this year.
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NFL rushing leaders after Week 5
Jonathan Taylor and the Colts continue their successful run as the back leads the NFL in rushing after five weeks.
So I'm supposed to be giving you some picks for Week 6 right now, but before that can happen, I need to make sure that CBS Sports hasn't banned me from making picks after what happened in Week 5. I had my worst week of the season and it wasn't close.
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NFL Week 6 betting, odds, lines: 5 biggest storylines, including an all-time survival pool bad beat
Jason Lisk at PoolGenius ranked the worst survival pool bad beats, and he had the Cardinals' 22-21 loss on Sunday at No. 1. It's hard to argue. If you're still alive for Week 6 because you didn't pick the Cardinals (or Rams, or Bills), then you're already playing with house money.