This study offers important insight into the pathogenic basis of intragenic frameshift deletions in the carboxy-terminal domain of MECP2, which account for some Rett syndrome cases, yet similar ...

Humans have it. So does Drosophila. But not yeast. That "it" is a small pause at the start of gene activity—a brief molecular halt that may have helped life evolve from simple cells to complex animals ...

Northwestern Medicine scientists have discovered how molecular "traffic controllers" in cells influence aging and cellular ...

Tuberculosis is both curable and preventable, yet each year, it still kills more people than any other infectious disease.

Fabrice Gritti, consultant scientist at Waters Corporation, spoke to LCGC International about the history of slalom chromatography (SC) and why he decided that the technique was worth re-investigating ...

Abstract: A defective double stranded poly(dG)-poly(dC) DNA molecule under axial mechanical strain is analyzed using a tight-binding computational model which allows calculation of the transmission ...

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FANCM binds and remodels replication fork structures in vitro. We report that in vivo, FANCM controls DNA chain elongation in an ATPase‐dependent manner. In the presence of replication inhibitors that ...

ABSTRACT: Transcription is a highly regulated cellular process in which dysfunction leads to disease. One level of regulation is chromatin structure which protects promoters from transcription factor ...