University of Southern California-led researchers have discovered the structural details of a brain receptor called GPR6, which could lead to new treatments for Parkinson's disease. GPR6 is an orphan ...

Bitter taste receptors are not only expressed in oral cavity cells but also in the gastrointestinal lining. To understand the diverse functions of these receptors, understanding the structure is ...

A research team has identified a molecular mechanism that coordinates the operation of the N-methyl-D-aspartate (NMDA) glutamate receptor, which is key to regulating excitatory synapse function in the ...

The brain’s cerebellum plays a key role in coordinating movement, balance, and cognition. Injury to the cerebellum can have a profound impact on basic motor skills, such as sitting, standing, and ...

Taste, pain, or response to stress—nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers at the University of ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

A new study reveals how partial subunit binding locks the brain's most common kainate receptor into a permanently open state.

Researchers have uncovered how a protein called MRAP2 acts as a key regulator of hunger. It helps move the appetite receptor MC4R to the cell’s surface, allowing it to send stronger “stop eating” ...

The latest update to the ESM protein language model series supports binder design and protein function mapping for therapeutic discovery.