If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...

Escherichia coli replicates its genome through a finely tuned ensemble of proteins that assemble at the replication fork to form the replisome. Central to this machinery are the DNA polymerase III ...

The ability to precisely edit the genomes of bacteria has long been a goal of microbiologists. Such technology would enable scientists to make new inroads into studying disease, developing sustainable ...

We have gone further than ever before in creating life that is unlike anything that has evolved naturally. The genome of an Escherichia coli bacterium has been redesigned on a computer to use just 57 ...

Escherichia coli relies on a sophisticated suite of pathways to maintain genomic integrity in the face of endogenous metabolic by-products and exogenous agents. Direct reversal mechanisms, exemplified ...

Scientists have uncovered new clues about why diabetic foot infections can become so severe and difficult to treat. By analyzing the DNA of E. coli bacteria taken from infected wounds around the world ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...