Schizophrenia (SCZ) is a psychiatric disorder with onset in adulthood, and is thought to be triggered by some combination of environmental factors and genetics. However, the exact cause of the ...

In 1992, Judith Frydman, PhD, discovered a molecular complex with an essential purpose in all of our cells: folding proteins correctly. The complex, a type of "protein chaperone" known as TRiC, helps ...

Researchers at Baylor College of Medicine have uncovered a previously unrecognized mechanism by which inherited calcium channel mutations disrupt early brain development and predispose children to ...

Researchers discover that diverse genetic causes of autism converge on shared cell types and temporary maturation delays during early brain development.

The cytoskeleton gives cells their shape and helps them move. Researchers at Helmholtz Munich and Ludwig Maximilian University now show that, in neural stem cells, proteins of the cytoskeleton are ...

Hundreds of genes have been linked to autism, yet the precise molecular and cellular mechanisms behind it remain largely ...

Schizophrenia is thought to affect 1 in 300 people, or about 0.32 percent of the global population, and treatment options are limited because of a poor understanding of the mechanisms underlying the ...

Psoriasis is a chronic inflammatory immune-mediated disease that causes patches of skin to become flaky or sore. The current cause of the condition is unknown and it is estimated that 125 million ...

Low-density lipoprotein receptor-related protein 4 (LRP4) has emerged as a central modulator of skeletal patterning and homeostasis through its capacity to regulate canonical Wnt/β-catenin signalling.

Little is known about the origin of germ cells in humans. We previously leveraged post-zygotic mutations to reconstruct zygote-rooted cell lineage ancestry trees in a phenotypically normal woman, ...