Current approaches to mapping fork progression in the human genome suffer from drastically low throughput. Here, we introduce ForkML, a nanopore sequencing-based method automatically positioning ...
PARP inhibitors (PARPi), known for their ability to induce replication gaps and accelerate replication forks, have become potent agents in anticancer therapy. However, the molecular mechanism ...
DNA repair mechanism: HELQ helicase remodels stalled replication forks into stable structures, preventing harmful mutations under replication stress. Advanced imaging tool: RF-SIRF maps reversed forks ...
A representative figure showing that HELQ-deficient cells fail to undergo normal fork slowing after MMC (a crosslinking agent) treatment, consistent with defective fork reversal. Every time a cell ...
If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...
Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...
Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...
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