RNA polymerase II (Pol II) pause release and transcriptional elongation involve phosphorylation of TRIM28 by the DNA damage response (DDR) kinases. Here, Bunch et al. show that DDR signalling is ...

During elongation, the new RNA strand becomes longer and longer as the DNA template is transcribed. In this view, the 5' end of the RNA strand is in the foreground.

Pol I begins the process of DNA elongation at a point called the “origin of replication” and about 400 base pairs downstream of this point, Pol III takes over replication, which it performs at ...

Elf1 forms an entry tunnel that helps thread the DNA into the polymerase and keep it in place. Spt4 and 5 make up an exit tunnel that separates DNA from RNA and ensures efficient exit of DNA and ...

By measuring ligand-induced DNA elongation at different ligand concentrations, they determined the binding constant and site size as a function of force.

Mitochondrial deoxyribonucleic acid (mtDNA) is essential for cellular energy production and overall cell function.

Protein synthesis is vital for life, translating genetic information from DNA to functional proteins through transcription and translation processes.

Genomic DNA was isolated from skin fibroblasts from the index patient and from blood of the parents, the sibling, and 100 controls. The DNA was amplified and digested with the restriction enzyme MseI.

An old drug gets a new look: DNA damaging agent aclarubicin found to disrupt chromatin and stimulate RNA Pol II elongation ... Aclarubicin stimulates RNA polymerase II elongation at closely spaced ...

Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial disease ...

Elf1 forms an entry tunnel that helps thread the DNA into the polymerase and keep it in place. Spt4 and 5 make up an exit tunnel that separates DNA from RNA and ensures efficient exit of DNA and ...