Many diseases are driven by proteins interacting with each other inside cells. But blocking these interactions with drugs is ...

A new method screens large libraries of synthetic cyclic peptides to identify compounds that can enter cells for therapeutic effect.

Conformational analysis of cyclic compounds examines the three-dimensional shapes that rings can adopt and the energy barriers between these shapes. In six‐membered rings, the chair form generally ...

Membrane-permeable cyclic peptide that inhibits the intracellular Keap1-Nrf2 protein-protein interaction. Credit: Christian ...

MS/MS sensitivity paired with multipass Cyclic™ Ion Mobility Spectrometry (IMS) reveals subtle biological differences for ...