De Armas has been married once to the Spanish actor Marc Clotet from 2011 to 2013. The Cuban actress was only 22 when she tied the knot and it came well before her Hollywood breakthrough in the late 2010s. She dated Ben Affleck after meeting the actor while filming Deep Water in 2019. They are said to have split up in 2021.

"Top Gun" star Tom Cruise has been linked to Cher, Penélope Cruz and Melissa Gilbert, along with his three marriages.

Ana de Armas has drawn attention online after fans noticed she liked a controversial Instagram post about Nicole Kidman, the ex-wife of Tom Cruise. The interaction, which remains visible as of publication, comes as ongoing rumors about a romantic relationship between de Armas and Cruise.